August 1, 1993Journal of VirologyOpen Access

Multiple binding sites for cellular proteins in the 3' end of Sindbis alphavirus minus-sense RNA

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Population

Mosquito cell extracts and labeled riboprobes representing the 3' end of Sindbis virus minus-sense RNA, Ross…

Design

Preclinical

Authors

NPNathalie PardigonInstitut Pasteur ELEdith M. LenchesUniversity of Bern JSJ H StraussCalifornia Institute of Technology

Discussion

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Implication

May represent a key step in alphavirus RNA replication; leaves open the proteins' identity and necessity in cellular infection.

Structured PICO

Population

Mosquito cell extracts and labeled riboprobes representing the 3' end of Sindbis virus minus-sense RNA, Ross River virus, Semliki Forest virus, and rubella virus

Intervention

Deletion mapping and binding assays

Outcome

Binding affinity to 50- and 52-kDa proteinssurrogate

The binding of 50- and 52-kDa proteins to the 3' end of alphavirus minus-sense RNA may represent an important step in the initiation of RNA replication.

Cite This Study

Pardigon et al. (1993) studied this question.

synapsesocial.com/papers/6a95b96c3ea7ffc69dbaeb12 https://doi.org/10.1128/jvi.67.8.5003-5011.1993

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Multiple binding sites for cellular proteins in the 3' end of Sindbis alphavirus minus-sense RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Multiple binding sites for cellular proteins in the 3' end of Sindbis alphavirus minus-sense RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider