Key result
Drug-coated balloons demonstrate safety and efficacy for de-novo coronary bifurcation lesions, though methodological limitations in current studies prevent definite recommendations.
Why the study?
Coronary bifurcation lesions remain a challenging PCI scenario, and although DCBs have shown safety and efficacy in de-novo lesions, study heterogeneity and methodological limitations have prevented definite recommendations.
Do drug-coated balloons improve outcomes in patients with coronary bifurcation lesions?
Do drug-coated balloons improve outcomes in patients with coronary bifurcation lesions?
Drug-coated balloons represent a promising 'leaving nothing behind' strategy for coronary bifurcation lesions, though further robust studies are needed to establish definitive recommendations.
DCBs remain investigational for bifurcation lesions; leaves open need for definitive RCTs before practice change.
Coronary bifurcation lesion (CBL) is a common but challenging scenario in percutaneous coronary interventions. Drug-coated balloons (DCBs) are modern devices with attractive perspective in CBL treatment. In-stent restenosis, small vessel and diffuse de-novo coronary artery disease have been, so far, considered the ideal scenario for DCBs application. Studies assessing DCBs in de-novo CBL demonstrated the safety and efficacy of this strategy. However, the heterogeneity of the study populations and the presence of methodological limitations prevent from drawing definite recommendations. Considering that the best treatment of bifurcations has not yet been defined, the "leaving nothing behind" philosophy will be the topic of future studies.
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Buono et al. (2021) conducted a review in Coronary bifurcation lesion. Drug-coated balloons (DCBs) was evaluated. Drug-coated balloons demonstrate safety and efficacy for de-novo coronary bifurcation lesions, though methodological limitations in current studies prevent definite recommendations.
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