Key result
Electroconvulsive therapy using methohexital showed no significant difference in clinical recovery (GAF increase 26.4 vs 24.8; P>0.1) or overall seizure duration compared to thiopental.
Why the study?
Does methohexital compared to thiopental affect seizure duration and clinical improvement in patients undergoing electroconvulsive therapy?
Population
97 patients receiving 837 electroconvulsive therapy treatments between January 2, 2002, and May 31, 2003
Comparison
Methohexital anesthetic during electroconvulsive… vs Thiopental anesthetic during electroconvulsive…
Design
Cohort
Follow-up
Hospital admission to discharge
Authors
Loading...
Should not yet change ECT anesthetic choice; leaves open whether randomized trials would confirm equivalence.
Observational (n=97)
Does methohexital compared to thiopental affect seizure duration and clinical improvement in patients undergoing electroconvulsive therapy?
Absolute Event Rate: 26.4% vs 24.8%
p-value: p=>0.1
The choice between methohexital and thiopental for electroconvulsive therapy anesthesia does not significantly affect clinical recovery, despite minor differences in seizure duration.
Dew et al. (2005) conducted an observational in Patients receiving electroconvulsive therapy (n=97). Methohexital vs. Thiopental was evaluated on Global Assessment of Functioning (GAF) score improvement at hospital discharge (p=>0.1). Electroconvulsive therapy using methohexital showed no significant difference in clinical recovery (GAF increase 26.4 vs 24.8; P>0.1) or overall seizure duration compared to thiopental.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: