Key result
Post-natal overfeeding and high-fat diet increased plasma renin activity and adipose (pro)renin receptor expression in adult rats, correlating with disproportionate adipocyte hypertrophy.
Early life overfeeding combined with a high-fat diet increases plasma renin activity and adipose (pro)renin receptor expression in rats, potentially contributing to adipocyte hypertrophy and glucose intolerance.
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Hypothesis-generating for early overfeeding in renin-mediated adiposity; leaves open human relevance and requires prospective confirmation.
BACKGROUND: Early life nutritional environment plays an important role in the development of visceral adipose tissue and interacts with nutritional regulations in adulthood, leading to metabolic dysregulations. AIM: We hypothesized that the renin-angiotensin system may play a role in the programming-induced development of visceral adipose tissue. MATERIAL AND METHODS: We studied, using a model of programming of overweight and glucose intolerance, obtained by post-natal overfeeding with consecutive highfat diet, the status of plasma renin activity and mesenteric adipose renin-angiotensin system, including the recently identified (pro)renin receptor, in adult rats. RESULTS: Post-natal overfeeding or high-fat feeding lead to overweight with increased visceral fat mass and adipocytes surface. When both paradigms were associated, adipocytes surface showed a disproportionate increase. A strong immunoreactivity for (pro)renin receptor was found in stromal cells. Plasma renin activity increased in programmed animals whereas (pro)renin receptor expressing cells density was stimulated by high-fat diet. There was a positive, linear relationship between plasma renin activity and (pro)renin receptor expressing cells density and adipocytes surface. CONCLUSIONS: Our experiments demonstrate that association of post-natal overfeeding and high-fat diet increased plasma renin activity and adipose (pro)renin receptor expression. Such phenomenon could explain, at least in part, the associated disproportionate adipocyte hypertrophy and its accompanying increased glucose intolerance.
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Achard et al. (2011) studied Overweight and glucose intolerance. Post-natal overfeeding and high-fat diet was evaluated on Plasma renin activity and mesenteric adipose (pro)renin receptor expression. Post-natal overfeeding and high-fat diet increased plasma renin activity and adipose (pro)renin receptor expression in adult rats, correlating with disproportionate adipocyte hypertrophy.
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