Key result
Patients with congenitally corrected transposition of the great arteries had significantly lower coronary flow reserve compared to healthy controls (mean 2.5 and 2.6 vs 4.0; p < 0.001).
Why the study?
Is myocardial blood flow and coronary flow reserve impaired in unoperated patients with congenitally corrected transposition of the great arteries compared to healthy controls?
Population
15 unoperated patients with congenitally corrected transposition of the great arteries, including 7 with…
Comparison
Positron emission tomography with nitrogen-13… vs Healthy adult controls
Design
Cross-sectional
Authors
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Impaired CFR in asymptomatic ccTGA suggests microcirculatory dysfunction; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=26)
No
Is myocardial blood flow and coronary flow reserve impaired in unoperated patients with congenitally corrected transposition of the great arteries compared to healthy controls?
p-value: p=< 0.001
Patients with congenitally corrected transposition of the great arteries have impaired coronary flow reserve even in the absence of ischaemic symptoms, suggesting microcirculatory dysfunction.
M. Häuser (2003) conducted a cross-sectional in Congenitally corrected transposition of the great arteries (n=26). Congenitally corrected transposition of the great arteries vs. Healthy adults was evaluated on Coronary flow reserve (p=< 0.001). Patients with congenitally corrected transposition of the great arteries had significantly lower coronary flow reserve compared to healthy controls (mean 2.5 and 2.6 vs 4.0; p < 0.001).
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