Key result
Temporary 12-month treatment with candesartan in young adults at high familial risk of hypertension had no persistent effect on blood pressure at 12 and 24 months post-withdrawal.
Why the study?
Does early treatment with candesartan persistently lower blood pressure after treatment withdrawal in young normotensive offspring of hypertensive parents?
Population
110 healthy normotensive subjects aged 18 to 36 years where both parents have essential hypertension
Comparison
Candesartan 16 mg once daily for 12 months vs Placebo for 12 months
Design
RCT, Randomly assigned to 1 of 2 treatment groups, Double-blind
Follow-up
12 months intervention with 24 months of follow-up
Authors
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Temporary candesartan confers no lasting BP benefit; challenges preventive short-term ARB strategies and reinforces sustained therapy in high-risk young adults.
RCT (n=110)
Double-blind
Randomly assigned
Does early treatment with candesartan persistently lower blood pressure after treatment withdrawal in young normotensive offspring of hypertensive parents?
Temporary treatment with an angiotensin-receptor blocker in young adults at high familial risk of hypertension lowers blood pressure during treatment but has no persistent effect after withdrawal.
Skov et al. (2007) conducted an RCT in High familial risk of future hypertension (n=110). Candesartan vs. Placebo was evaluated on Mean 24-hour ambulatory blood pressure recordings (mean AMBP) after 12 and 24 months follow-up. Temporary 12-month treatment with candesartan in young adults at high familial risk of hypertension had no persistent effect on blood pressure at 12 and 24 months post-withdrawal.
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