December 18, 2015Transplantation
Nocturnal Hypertension and Altered Night–Day BP Profile and Atherosclerosis in Renal Transplant Patients
Key result
The night-day systolic blood pressure ratio was independently associated with intima-media thickness in renal transplant patients (β = 0.14, P = 0.04), whereas daytime and clinic BP were not.
Why the study?
Does ambulatory blood pressure monitoring, specifically nighttime BP and night-day ratio, associate with intima-media thickness in renal transplant patients?
Population
172 renal transplant patients at a single institution
Comparison
Ambulatory blood pressure monitoring focusing on… vs Clinic blood pressure and daytime/24-hour ABPM
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
May enhance CV risk stratification via ABPM in renal transplant recipients; leaves open whether nighttime BP reduction improves outcomes.
Study Design
Type
Cross-Sectional (n=172)
Multicenter
No
Structured PICO
Does ambulatory blood pressure monitoring, specifically nighttime BP and night-day ratio, associate with intima-media thickness in renal transplant patients?
P
Population
172 renal transplant patients evaluated for the association between ambulatory blood pressure monitoring metrics and intima-media thickness at a single institution.
E
Exposure
Ambulatory blood pressure monitoring (ABPM) focusing on nighttime BP and night-day ratio
C
Comparator
Clinic blood pressure and daytime/24-hour ABPM
O
Outcome
Intima-media thickness (IMT) measured by echo-color Dopplersurrogate
Main Result
Effect estimate: β = 0.14
p-value: p=0.04
In renal transplant patients, nighttime systolic BP and the night-day ratio are independently associated with intima-media thickness, suggesting ABPM provides unique cardiovascular risk information beyond clinic BP.
Cite This Study
Mallamaci et al. (2015) conducted a cross-sectional in Renal transplant patients (n=172). Nighttime systolic BP and night-day BP ratio vs. Daytime BP and clinic BP was evaluated on Intima-media thickness (IMT) (β = 0.14, p=0.04). The night-day systolic blood pressure ratio was independently associated with intima-media thickness in renal transplant patients (β = 0.14, P = 0.04), whereas daytime and clinic BP were not.