Key result
Phylogenetic analysis revealed that FAdV-4 isolates from chickens with hydropericardium syndrome in Japan were identical to each other but completely distinct from strains from India and Pakistan.
FAdV-4 strains causing hydropericardium syndrome in chickens in Japan are genetically distinct from those in India and Pakistan, suggesting a different origin.
May indicate separate viral introductions in Japan; hypothesis-generating for region-specific surveillance and control in poultry.
We genetically characterized fowl adenoviruses (serotype 4 FAdV, FAdV-4) isolated from chickens with hydropericardium syndrome (HPS) in Japan by the polymerase chain reaction (PCR) method coupled with direct sequencing. Phylogenetic analysis based on the part of the hexon gene that included the L1 region revealed that all FAdV-4 isolates from chickens with HPS in Japan were identical and were distinguished completely from the cluster including FAdV strains from chickens with HPS in India and Pakistan. This suggested that FAdV-4 from the HPS chickens in India and Pakistan was derived from a common ancestor, but the origin of the FAdV-4 from the HPS chickens in Japan was completely different.
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Mase et al. (2009) studied Hydropericardium syndrome (HPS) in chickens. Genetic characterization (PCR and sequencing) vs. Old conventional FAdV-4 strains was evaluated on Phylogenetic relationship of FAdV-4 isolates based on the hexon gene. Phylogenetic analysis revealed that FAdV-4 isolates from chickens with hydropericardium syndrome in Japan were identical to each other but completely distinct from strains from India and Pakistan.
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