Key result
In heart failure patients without baseline LV dyssynchrony, induction of LV dyssynchrony ≥40 ms after CRT was associated with higher 3-year mortality compared to <40 ms (23% vs 10%; P<0.001).
Why the study?
Does the induction of LV dyssynchrony after CRT increase all-cause mortality in heart failure patients without baseline LV dyssynchrony?
Cohort (n=580)
Does the induction of LV dyssynchrony after CRT increase all-cause mortality in heart failure patients without baseline LV dyssynchrony?
Hazard Ratio: 1.247
Absolute Event Rate: 23% vs 10%
p-value: p=0.009
In heart failure patients without baseline LV dyssynchrony, CRT can induce mechanical dyssynchrony which is associated with increased long-term mortality.
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CRT-induced LV dyssynchrony was associated with higher mortality; leaves open whether optimization improves outcomes in non-dyssynchronous HF.
Auger et al. (2012) conducted a cohort in heart failure (n=580). Induction of LV dyssynchrony after CRT (≥40 ms) vs. LV dyssynchrony <40 ms after CRT was evaluated on All-cause mortality (HR 1.247, p=0.009). In heart failure patients without baseline LV dyssynchrony, induction of LV dyssynchrony ≥40 ms after CRT was associated with higher 3-year mortality compared to <40 ms (23% vs 10%; P<0.001).