Key result
Coronary artery disease was associated with significantly greater corrected QT dispersion in the morning hours compared to having normal coronary angiograms (p < 0.001).
Why the study?
Does corrected QT dispersion show circadian variation in patients with coronary artery disease compared to those with normal coronary angiograms?
Population
110 patients referred for coronary angiography, including 62 with double- or triple-vessel coronary artery…
Design
Cross-sectional
Follow-up
1 day (day after coronary angiography)
Authors
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May signal morning arrhythmic vulnerability in CAD; hypothesis-generating for QT dispersion monitoring, requiring prospective validation before clinical use.
Observational (n=110)
Does corrected QT dispersion show circadian variation in patients with coronary artery disease compared to those with normal coronary angiograms?
p-value: p=<0.001
QTc dispersion exhibits a circadian variation with a morning peak in patients with coronary artery disease, potentially explaining the morning increase in sudden cardiac death.
Batur et al. (1999) conducted an observational in Coronary artery disease (n=110). Coronary artery disease vs. Normal coronary angiograms was evaluated on Corrected QT dispersion (QTcD) in the morning hours (p=<0.001). Coronary artery disease was associated with significantly greater corrected QT dispersion in the morning hours compared to having normal coronary angiograms (p < 0.001).
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