Why the study?
Does QT dispersion exhibit diurnal variation in patients with chronic heart failure?
Does QT dispersion exhibit diurnal variation in patients with chronic heart failure?
QT dispersion exhibits a clear diurnal variation in patients with chronic heart failure, with increased dispersion in the afternoon, which may have implications for the timing of sudden cardiac death.
May inform diurnal arrhythmia risk assessment in heart failure; hypothesis-generating and requires prospective validation before practice implications.
QT dispersion is defined as the difference in QT interval among the different leads of the standard 12-lead electrocardiogram and reflects inhomogeneity of myocardial repolarization. Dispersion of repolarization is an important electrophysiologic feature that is considered fundamental for the initiation of ventricular fibrillation. However, no data exist regarding the diurnal variation of QT dispersion measured from simultaneous 12-lead recording in chronic heart failure patients. The aim of this study was to identify diurnal variation in QT dispersion in patients with chronic heart failure. QT dispersion was measured in the 12-lead standard electrocardiogram in 11 patients with chronic heart failure. QT dispersion in these patients was increased in the afternoon compared to the morning. It is concluded that QT dispersion has a clear diurnal variation in patients with chronic heart failure. These findings have potentially significant implications for therapy and prevention of sudden cardiac death in patients with chronic heart failure.
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Kinoshita et al. (2005) studied this question.
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