September 29, 2017European Heart Journal
First in human transcatheter COMBO mitral valve repair with direct ring annuloplasty and neochord leaflet implantation to treat degenerative mitral regurgitation: feasibility of the simultaneous toolbox concept guided by 3D echo and computed tomography fusion imaging
Key result
A first-in-human simultaneous transcatheter direct annuloplasty and chordal implantation was successfully performed in a high-risk patient with severe mitral regurgitation.
Study Design
Type
Case Report (n=1)
Structured PICO
P
Population
A 63-year-old male with severe mitral regurgitation and high surgical risk underwent a first-in-human simultaneous transcatheter direct annuloplasty and chordal implantation.
I
Intervention
Transvenous transcatheter off-pump direct annuloplasty (Edwards Cardioband) and simultaneous one-staged transapical off-pump transcatheter implantation of three NeoChordae (NeoChord DS1000) guided by 3D echocardiography and CT fusion imaging.
O
Outcome
Procedural feasibility
This first-in-human case demonstrates the feasibility of a simultaneous transcatheter mitral valve repair combining direct ring annuloplasty and neochord leaflet implantation for severe degenerative mitral regurgitation in a high-risk patient.
Authors
Discussion
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Implication
Hypothesis-generating for combined transcatheter mitral repair; prospective trials needed before clinical adoption.
Cite This Study
Bardeleben et al. (2017) conducted a case report in Severe mitral regurgitation (n=1). Simultaneous transcatheter direct annuloplasty (Cardioband) and chordal implantation (NeoChord) was evaluated on Procedural feasibility. A first-in-human simultaneous transcatheter direct annuloplasty and chordal implantation was successfully performed in a high-risk patient with severe mitral regurgitation.