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September 1, 2001Journal of EndocrinologyOpen Access

Trout IGFBP inhibited IGF-I-stimulated DNA synthesis and cell proliferation in a concentration-dependent manner, with an inhibitory effect comparable to human IGFBP-1 and -4.

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Population

Rainbow trout (Oncorhynchus mykiss) serum, cultured trout hepatoma cells, and cultured fish and human cells

Comparison

Purified 30 kDa trout IGF-binding protein (IGFBP) vs Human IGFBP-1 and -4

Design

Preclinical

Key result

Trout IGFBP inhibited IGF-I-stimulated DNA synthesis and cell proliferation in a concentration-dependent manner, with an inhibitory effect comparable to human IGFBP-1 and -4.

Authors

AGAaron GarmongPSPenny SwansonJMJerome A. Moore

Discussion

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Overview

Trout IGFBP functionally conserved with human isoforms; extends evolutionary insights but leaves open any clinical relevance.

Structured PICO

P
Population
Rainbow trout (Oncorhynchus mykiss) serum, cultured trout hepatoma cells, and cultured fish and human cells
I
Intervention
Purified 30 kDa trout IGF-binding protein (IGFBP)
C
Comparator
Human IGFBP-1 and -4
O
Outcome
Binding affinity to IGFs, N-terminal sequence identity, and effect on IGF-I-stimulated DNA synthesis and cell proliferationsurrogate

The IGFBP molecule is structurally and functionally conserved in evolutionarily ancient vertebrate species such as bony fish.

Cite This Study

Garmong et al. (2001) studied this question. Trout IGFBP vs. Human IGFBP-1 and -4 was evaluated on Inhibition of IGF-I-stimulated DNA synthesis and cell proliferation. Trout IGFBP inhibited IGF-I-stimulated DNA synthesis and cell proliferation in a concentration-dependent manner, with an inhibitory effect comparable to human IGFBP-1 and -4.

synapsesocial.com/papers/6a96708c672df19136a6bcd4https://doi.org/10.1677/joe.0.1700619
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcriptome analysis reveals IGF-dependent and IGF-independent mechanisms affected by loss of IGF binding protein-2b in rainbow trout2026
  2. 2Salmon serum 22 kDa insulin-like growth factor-binding protein (IGFBP) is IGFBP-12005 · 46 citations
  3. 3Insulin-like growth factor binding protein 2 is a growth inhibitory protein conserved in zebrafish1999 · 128 citations
  4. 4Quantitation of IGF-I, IGF-II, and multiple insulin receptor family member messenger RNAs during embryonic development in rainbow trout1999 · 62 citations
  5. 5Development of an RIA for salmon 41 kDa IGF-binding protein2003 · 45 citations