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March 11, 2009AJP Regulatory Integrative and Comparative Physiology

Overexpressing zebrafish IGFBP-6a and IGFBP-6b reduces body size and developmental rate without altering cell fate.

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Population

Zebrafish (adult fish and embryos)

Design

Preclinical

Key result

Overexpression of zebrafish IGFBP-6a and IGFBP-6b caused a similar degree of reduction in body size and developmental rate without notable effects on cell fate or patterning.

Authors

XWXianlei WangLLLing LüYLYun Li

Discussion

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Overview

Zebrafish overexpression data implicate IGFBP-6 in somatic growth; leaves open conservation and relevance to human development.

Structured PICO

P
Population
Zebrafish (adult fish and embryos)
I
Intervention
Overexpression of zebrafish IGFBP-6a and IGFBP-6b
O
Outcome
Gene expression patterns, body size, developmental rate, cell fate, and patterning

The study identifies two functional IGFBP-6 genes in zebrafish that encode functionally similar proteins but have evolved distinct spatial and temporal expression patterns.

Cite This Study

Wang et al. (2009) studied this question. Overexpression of zebrafish IGFBP-6a and IGFBP-6b was evaluated on Body size and developmental rate. Overexpression of zebrafish IGFBP-6a and IGFBP-6b caused a similar degree of reduction in body size and developmental rate without notable effects on cell fate or patterning.

synapsesocial.com/papers/6aa5fee466012019823a560bhttps://doi.org/10.1152/ajpregu.90969.2008
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