Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 15, 2010The FASEB Journal

Zebrafish IGFBP-5a and -5b both bind IGF and localize to the nucleus, but IGFBP-5a lacks transactivation activity due to two unique amino acids at positions 22 and 56.

View Full Paper
Ask AI
Bookmark
Share

Population

Zebrafish and cultured cells

Design

Preclinical

Authors

WDWei DaiHKHiroyasu KameiYZYang Zhao

Discussion

Loading...

Member takes

Overview

Zebrafish IGFBP-5 duplication shows partitioned nuclear activity; extends evolutionary models but leaves open human cardiovascular IGF relevance.

Structured PICO

P
Population
Zebrafish and cultured cells
I
Intervention
Mutational analysis of zebrafish IGFBP-5a and -5b genes
O
Outcome
IGF binding, nuclear localization, and transactivation activitysurrogate

The duplicated zebrafish IGFBP-5 genes have evolved divergent regulatory mechanisms through partitioning of ancestral structural domains.

Cite This Study

Dai et al. (2010) studied this question.

synapsesocial.com/papers/6a76ae659ba60942f10619eehttps://doi.org/10.1096/fj.09-149435
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular and functional characterization of two distinct IGF binding protein-6 genes in zebrafish2009 · 61 citations
  2. 2Insulin-like growth factor binding protein 2 is a growth inhibitory protein conserved in zebrafish1999 · 128 citations
  3. 3Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease2020 · 114 citations
  4. 4Evidence That IGF Binding Protein-5 Functions as a Ligand-Independent Transcriptional Regulator in Vascular Smooth Muscle Cells2004 · 92 citations
  5. 5Evolution of the Insulin-Like Growth Factor Binding Protein (IGFBP) Family2011 · 153 citations