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December 21, 1999Proceedings of the National Academy of SciencesOpen Access

Zebrafish IGFBP-2 significantly inhibited IGF-I-stimulated cell proliferation and DNA synthesis when overexpressed or added to cultured cells.

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Population

Zebrafish, Chinese hamster ovary cells, and cultured zebrafish and mammalian cells

Comparison

Overexpression or addition of zebrafish IGFBP-2… vs Control conditions

Design

Preclinical

Authors

CDCunming DuanJDJun DingQLQin Li

Discussion

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Overview

No immediate clinical implications; extends evidence for evolutionary conservation of IGFBP-2 inhibition, warranting mammalian studies.

Structured PICO

P
Population
Zebrafish (embryonic and adult tissues), Chinese hamster ovary cells, and cultured zebrafish and mammalian cells
I
Intervention
Overexpression or addition of zebrafish IGFBP-2; growth hormone treatment; prolonged fasting
C
Comparator
Control conditions
O
Outcome
IGF-I-stimulated cell proliferation and DNA synthesissurrogate

Zebrafish IGFBP-2 acts as a negative growth regulator downstream in the growth hormone-IGF-I axis, demonstrating evolutionary conservation of its growth inhibitory function.

Cite This Study

Duan et al. (1999) studied this question.

synapsesocial.com/papers/6a896149a7eee2293bcafb75https://doi.org/10.1073/pnas.96.26.15274
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Also Consider

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  5. 5Regulation and Function of Insulin-Like Growth Factor-Binding Protein-11993 · 391 citations