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August 7, 2026Physiological GenomicsOpen Access

Transcriptome analysis reveals IGF-dependent and IGF-independent mechanisms affected by loss of IGF binding protein-2b in rainbow trout

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Authors

BCBeth M. ClevelandLRLisa RadlerMSMunetaka Shimizu

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Overview

Transcriptome analysis reveals changes in muscle growth and immune function in rainbow trout lacking IGFBP-2b, suggesting implications for growth regulation.

Key Points

  • This research aims to determine the biological mechanisms influenced by the loss of IGFBP-2b in rainbow trout.
  • Gene edited rainbow trout lacking IGFBP-2b were compared to wild type controls.
  • Transcriptomic analysis was performed on liver and muscle tissues from both groups under fed and fasting conditions.
  • Differentially expressed genes (DEGs) were assessed to identify affected pathways.
  • Loss of IGFBP-2b led to reduced IGF-1 levels and enhanced muscle growth, with up-regulated myogenic mechanisms.
  • Hepatic functions were down-regulated, while muscle showed increased IGF-1 signaling.
  • Inhibition of immune and cytokine responses in liver was noted, indicating a role for IGFBP-2b in balancing growth and immune functions.

Cite This Study

Cleveland et al. (2026) studied this question.

synapsesocial.com/papers/6a758bae847ab6d26c01f0cfhttps://doi.org/10.1152/physiolgenomics.00102.2026
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