Key result
Persistent iatrogenic atrial septal defects occurred in 27% of patients at 12 months after MitraClip repair and were associated with lower freedom from MR >2+ (38% vs 83%, p=0.016).
Why the study?
What is the prevalence and echocardiographic features of iatrogenic atrial septal defect after catheter-based mitral valve repair with the MitraClip system?
Observational (n=30)
What is the prevalence and echocardiographic features of iatrogenic atrial septal defect after catheter-based mitral valve repair with the MitraClip system?
Absolute Event Rate: 38% vs 83%
p-value: p=0.016
Persistent iatrogenic ASDs occur in 27% of patients 12 months after MitraClip repair and are associated with less MR reduction, suggesting increased LA pressure may maintain the defect.
No takes yet. Share an insight, caveat, or question.
May warrant closer MR surveillance after MitraClip; leaves open whether defect closure improves outcomes in prospective trials.
Smith et al. (2012) conducted an observational in Mitral regurgitation (n=30). Iatrogenic atrial septal defect (iASD) vs. No iASD was evaluated on Freedom from MR > 2+ at 12 months (p=0.016). Persistent iatrogenic atrial septal defects occurred in 27% of patients at 12 months after MitraClip repair and were associated with lower freedom from MR >2+ (38% vs 83%, p=0.016).
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