Key result
Iatrogenic ASD closure post-MitraClip fails to significantly reduce RVSP compared to conservative management.
Why the study?
Iatrogenic atrial septal defect resulting from MitraClip procedures may cause volume overload and deterioration of right ventricular function, and the impact of routine iASD closure on RV function is unclear.
Does concomitant iASD closure with an occluder improve right ventricular function and hemodynamics in patients undergoing MitraClip?
Cohort (n=19)
Does concomitant iASD closure with an occluder improve right ventricular function and hemodynamics in patients undergoing MitraClip?
Absolute Event Rate: 11% vs 4%
p-value: p=0.35
Immediate closure of iatrogenic ASD after MitraClip may improve right ventricular-pulmonary artery coupling and reduce right ventricular systolic pressure, despite an observed reduction in TAPSE.
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iASD closure may enhance RV-PA coupling post-MitraClip; hypothesis-generating and requires randomized confirmation before practice change.
Streb et al. (2025) conducted a cohort in Iatrogenic atrial septal defect (iASD) resulting from MitraClip procedures (n=19). Concomitant iASD closure with Amplatzer occluder vs. iASD left untreated was evaluated on Reduction in right ventricular systolic pressure (RVSP) (p=0.35). Closure of iatrogenic atrial septal defects after MitraClip yielded an 11 mmHg reduction in RVSP versus 4 mmHg in untreated controls (P=0.35), alongside increased RV-PAc.
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