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June 1, 1992American Journal of Epidemiology

Influence of Body Fat and its Regional Localization on Risk Factors for Atherosclerosis in Young Men

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Key result

In 1,293 young men, excess total body fat was independently associated with a poor profile of risk factors for atherosclerosis, whereas central fat localization was not independently associated.

Why the study?

Is total body fat or its regional localization associated with atherosclerosis risk factors in young men?

Population

1,293 18-year-old men in Verona, Italy

Comparison

Total body fat and regional fat localization vs Different quartiles of total body fat and…

Design

Cross-sectional

Authors

EBEnzo BonoraMZM. ZenerePBPaola Branzi

Discussion

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Overview

Hypothesis-generating for total adiposity screening in young men; leaves open causality and longitudinal validation of fat distribution.

Study Design

Type

Cross-Sectional (n=1,293)

Multicenter

No

Structured PICO

Is total body fat or its regional localization associated with atherosclerosis risk factors in young men?

P
Population
1,293 18-year-old men evaluated for the relationship between body fat, its regional localization, and risk factors for atherosclerosis.
E
Exposure
Total body fat and regional fat localization (waist/hip ratio)
C
Comparator
Different quartiles of total body fat and waist/hip ratio
O
Outcome
Fasting serum levels of total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, insulin, systolic and diastolic blood pressuresurrogate

In young men, excess total body fat, rather than its central localization, is independently associated with a poor atherosclerosis risk profile.

Cite This Study

Bonora et al. (1992) conducted a cross-sectional in Risk factors for atherosclerosis (n=1,293). Excess body fat and central fat localization vs. Lower body fat and non-central fat localization was evaluated on Metabolic and hemodynamic risk factors for atherosclerosis (cholesterol, LDL, HDL, triglycerides, insulin, blood pressure). In 1,293 young men, excess total body fat was independently associated with a poor profile of risk factors for atherosclerosis, whereas central fat localization was not independently associated.

synapsesocial.com/papers/6a967d16dc355c9d4e897d74https://doi.org/10.1093/oxfordjournals.aje.a116233
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RELATION OF BODY FATNESS AND ITS DISTRIBUTION TO CARDIOVASCULAR RISK FACTORS IN YOUNG BLACKS AND WHITES1989 · 145 citations
  2. 2Relationship of Body Fat Distribution Pattern to Atherogenic Risk Factors in NIDDM: Preliminary Results1988 · 61 citations
  3. 3Regional Fat Deposition in the Legs Is Useful as a Presumptive Marker of Antiatherogenesity in Japanese2000 · 32 citations
  4. 4IS BODY FATNESS OR ITS DISTRIBUTION RELATED TO ENDOTHELIAL FUNCTION IN OLDER PERSONS?2001
  5. 5Behavioural Factors, Dietary Patterns and Fat Distribution in Young Men: Association with Cardiovascular Risk2025