Why the study?
Does urethane exert direct actions on vascular smooth muscle contraction in rat aortic strips and portal vein segments?
Population
Rat aortic strips and portal vein segments
Comparison
Urethane (10(-3) to 10(-1) M) vs Control (absence of urethane or post-washout)
Design
Preclinical
Authors
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Urethane may confound vascular reactivity studies under anesthesia; leaves open translation to in vivo hemodynamics or other species.
Does urethane exert direct actions on vascular smooth muscle contraction in rat aortic strips and portal vein segments?
Urethane at plasma concentrations commonly associated with surgical anesthesia can directly induce relaxation of vascular smooth muscle.
Altura et al. (1979) studied this question.