Population
Rats in vivo, anesthetized either with a mixture of ketamine/xylazine or with urethane
Comparison
Intravenous injection of endothelins and their… vs Comparison between different peptides and…
Design
Preclinical
Authors
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Anesthetic choice confounds endothelin pressor responses in rats; leaves open standardization needs before any translational relevance.
The choice of anesthetics (ketamine/xylazine vs urethane) significantly alters the pressor responses to endothelins in rat models, with urethane markedly blunting the response.
Gratton et al. (1995) studied this question.
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