Tests for Immunity to Acute Anterior Poliomyelitis

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Why the study?

Does intracutaneous injection of poliomyelitis vaccine or spinal cord suspension cause viral or allergic reactions in monkeys and humans?

Population

Macacus rhesus monkeys, 34 human adults, and 30 children.

Authors

Discussion

Mild reactions in small early cohorts support irritant etiology; leaves open need for controlled trials to assess vaccine safety at scale.

Does intracutaneous injection of poliomyelitis vaccine or spinal cord suspension cause viral or allergic reactions in monkeys and humans?

Population

Macacus rhesus monkeys (normal and previously vaccinated), 34 human adults, and 30 children (ages 8 months to 12 years).

Intervention

Intracutaneous injection of monkey poliomyelitis spinal cord suspensions, Kolmer vaccine, or Berkefeld filtrate of Kolmer vaccine.

Outcome

Local reactions to intracutaneous injectionssafety

Intracutaneous injection of poliomyelitis vaccine components primarily causes mild irritant reactions rather than viral or allergic responses.

Kolmer et al. (1935) studied this question.

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Mild reactions in small early cohorts support irritant etiology; leaves open need for controlled trials to assess vaccine safety at scale.