Experimental study demonstrates RGS14 suppresses cerebral ischemia-reperfusion injury in primary neurons, suggesting a novel therapeutic pathway for stroke.
BACKGROUND: Stroke is a crucial cause of morbidity and mortality worldwide. The regulator of G protein signaling 14 (RGS14) plays important roles in mediating multiple signaling pathways and various pathophysiological processes. However, the function of RGS14 in cerebral ischemic reperfusion injury (CIRI) remains unknown. METHODS AND CONCLUSIONS: These findings imply that RGS14 is a novel negative regulator and may serve as a potential therapeutic target for CIRI.
No takes yet. Share an insight, caveat, or question.
Zhou et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: