Key result
Human Immunodeficiency Virus (HIV) infection was associated with significantly higher Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio compared to control subjects (all p<0.01).
Why the study?
Are ventricular repolarization markers (Tp-e interval and Tp-e/QT ratio) altered in patients with HIV compared to control subjects?
Case-Control (n=108)
Are ventricular repolarization markers (Tp-e interval and Tp-e/QT ratio) altered in patients with HIV compared to control subjects?
p-value: p=<0.01
HIV infection is associated with prolonged Tp-e interval and increased Tp-e/QT ratios, suggesting altered ventricular repolarization which correlates with disease severity and duration.
Human Immunodeficiency Virus (HIV) infection and AIDS are known to cause cardiovascular diseases such as premature coronary artery disease, cardiomyopathy, and arrhythmias. Recently, Tp-e interval and Tp-e/QT ratio has been shown as a novel marker of ventricular repolarization. We aimed to evaluate the ventricular repolarization using Tp-e interval and Tp-e/QT ratio in patients with Human Immunodeficiency Virus (HIV) infection. Totally 48 patients with HIV and 60 control subjects were enrolled to the study. Tp-e interval, Tp-e/QT and Tp-e/QTc ratio were measured from the 12-lead electrocardiogram. Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio were significantly higher in patients with HIV than control subjects (all p<0.01). In correlation analysis, there were positive correlation between Tp-e interval and disease duration (r=0.298, p=0.048). and inverse correlation between Tp-e interval and CD4 count(r=-0.303, p=0.036). Our study showed that Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were increased in patients with HIV than control subjects.
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Ünal et al. (2017) conducted a case-control in Human Immunodeficiency Virus (HIV) infection (n=108). Human Immunodeficiency Virus (HIV) infection vs. Control subjects was evaluated on Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio (p=<0.01). Human Immunodeficiency Virus (HIV) infection was associated with significantly higher Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio compared to control subjects (all p<0.01).
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