Key result
HIV infection is linked to higher Tp-e intervals and Tp-e/QTc ratios versus controls.
Why the study?
The prevalence of cardiovascular disease and repolarization abnormalities in the HIV-infected population is increasing, but changes in Tp-e interval and related ratios have not been fully evaluated.
Does HIV infection increase ventricular repolarization dispersion (Tp-e interval, Tp-e/QTc ratio) compared to healthy controls?
Case-Control (n=235)
Does HIV infection increase ventricular repolarization dispersion (Tp-e interval, Tp-e/QTc ratio) compared to healthy controls?
p-value: p=0.006, 0.004, 0.003, 0.002
HIV infection is associated with prolonged Tp-e intervals and increased Tp-e/QTc ratios, which correlate with disease severity and may indicate an increased risk for ventricular arrhythmias.
May indicate heightened arrhythmia vulnerability in HIV; leaves open whether ECG markers predict events or warrant monitoring.
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Evren et al. (2020) conducted a case-control in Human Immunodeficiency Virus (HIV) infection (n=235). HIV infection vs. Uninfected controls was evaluated on Tp-e interval, cTp-e interval, Tp-e/QT and Tp-e/QTc ratios (p=0.006, 0.004, 0.003, 0.002). HIV infection was associated with significantly higher Tp-e interval, cTp-e interval, Tp-e/QT, and Tp-e/QTc ratios compared to controls (p=0.006, p=0.004, p=0.003, p=0.002).
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