Key result
Oral prazosin significantly decreased forearm venous tone from 44.5 to 14.3 mm Hg/ml (p<0.01) and forearm vascular resistance from 70.2 to 48.4 mm Hg/ml/100 gm/min (p<0.05).
Why the study?
Does oral prazosin reduce forearm venous tone and vascular resistance in subjects including those with chronic congestive heart failure?
Population
10 subjects, including 7 patients with chronic congestive failure due to coronary heart disease
Design
Case_series
Follow-up
at least 60 mins
Authors
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May support venodilation in chronic HF; case report leaves open clinical benefits pending controlled trials.
Does oral prazosin reduce forearm venous tone and vascular resistance in subjects including those with chronic congestive heart failure?
p-value: p=<0.01
Oral prazosin induces systemic venodilation and peripheral arteriolodilation, suggesting potential physiological benefits for relieving pulmonary congestion in patients with chronic congestive heart failure.
Awan et al. (1977) studied chronic congestive failure due to coronary heart disease (n=10). Prazosin was evaluated on Forearm venous tone (FVT) and forearm vascular resistance (FVR) (p=<0.01). Oral prazosin significantly decreased forearm venous tone from 44.5 to 14.3 mm Hg/ml (p<0.01) and forearm vascular resistance from 70.2 to 48.4 mm Hg/ml/100 gm/min (p<0.05).
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