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Smooth muscle myosin isoforms exhibit distinct detachment rate constants that regulate the responsiveness of the vascular smooth muscle cell contractile apparatus to calcium.
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Several myosin isoforms are expressed in smooth muscle, based upon both heavy and light chain polymorphisms. These myosin isoenzymes reveal distinct detachment rate constants, thus regulating the responsiveness of the VSMC contractile apparatus to Ca2+, as well as its energetical and mechanical behavior.
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Ingo Morano (1992) studied this question. Smooth muscle myosin isoforms exhibit distinct detachment rate constants that regulate the responsiveness of the vascular smooth muscle cell contractile apparatus to calcium.
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