Key result
Pindolol given twice-daily resulted in similar blood pressure control compared to thrice-daily dosing, suggesting it can be used in a twice-daily regimen for most cases.
Why the study?
Does twice-daily dosing of pindolol control blood pressure as effectively as thrice-daily dosing in patients with hypertension?
Population
16 patients with hypertension well controlled by pindolol alone or pindolol plus a diuretic
Comparison
Pindolol given in two divided doses daily for… vs Pindolol given in three divided doses daily for…
Follow-up
1 month per regimen
Authors
Loading...
Supports twice-daily pindolol convenience in hypertension; leaves open confirmation in randomized trials before practice change.
Does twice-daily dosing of pindolol control blood pressure as effectively as thrice-daily dosing in patients with hypertension?
Pindolol can be effectively administered in a twice-daily regimen for the control of hypertension in most cases, despite slightly lower afternoon plasma levels.
Waal‐Manning et al. (1975) studied Hypertension (n=16). Pindolol vs. Thrice-daily was evaluated on Afternoon lying and standing blood pressure, pulse rate and plasma pindolol levels. Pindolol given twice-daily resulted in similar blood pressure control compared to thrice-daily dosing, suggesting it can be used in a twice-daily regimen for most cases.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: