Key result
Transplantation of embryonic kidneys and labeling studies demonstrated that juxtaglomerular cells originate from the metanephric mesenchyme rather than an extrarenal source.
Population
Genetically marked and wild-type mice (embryonic kidneys E12 to E16)
Design
Preclinical
Authors
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Refines renin cell lineage in animal models; extends developmental tracing but leaves open human translation.
Juxtaglomerular cells originate from the metanephric mesenchyme, and renin cells are likely precursors to smooth muscle cells of renal arterioles.
Sequeira-Lόpez et al. (2001) studied Embryonic development of juxtaglomerular cells. Transplantation of embryonic kidneys and labeling studies was evaluated on Embryonic origin and lineage of the juxtaglomerular cell. Transplantation of embryonic kidneys and labeling studies demonstrated that juxtaglomerular cells originate from the metanephric mesenchyme rather than an extrarenal source.
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