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March 1, 1992AJP Cell Physiology

Juxtaglomerular cells cultured on a reconstituted basement membrane

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Population

Rat juxtaglomerular (JG) cells

Design

Preclinical

Authors

BRB. M. RaysonCornell University

Discussion

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Overview

Provides novel in vitro JG cell model for renin studies; leaves open translation to human physiology.

Structured PICO

P
Population
Rat juxtaglomerular (JG) cells
I
Intervention
Primary culture on a reconstituted basement membrane and transformation with a temperature-sensitive SV40 large T antigen gene
O
Outcome
Maintenance of a highly differentiated state and secretion of active renin

The successful primary culture and transformation of rat juxtaglomerular cells provides a novel in vitro system to study the cellular mechanisms regulating renin synthesis and release.

Cite This Study

B. M. Rayson (1992) studied this question.

synapsesocial.com/papers/6a842f01a47fb2e1cdb29a35https://doi.org/10.1152/ajpcell.1992.262.3.c563
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Also Consider

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  1. 1Molecular cloning of rat renin cDNA and its gene.1987 · 164 citations
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  3. 3Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature.1989 · 315 citations
  4. 4Expression of extracellular matrix components is regulated by substratum.1990 · 345 citations
  5. 5Nuclear Protein Matrix: Association with Newly Synthesized DNA1975 · 486 citations