Key result
Congenital bicuspid aortic valve pathogenesis is historically attributed to either the fusion of two adjacent valvular edges during fetal life or the failure of a valvular cusp to develop.
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May support classic bicuspid aortic valve models; leaves open validation in modern cohorts.
Bentivoglio et al. (1960) studied this question. Congenital bicuspid aortic valve pathogenesis is historically attributed to either the fusion of two adjacent valvular edges during fetal life or the failure of a valvular cusp to develop.