August 31, 2018Journal of Cardiovascular Electrophysiology
Developing a risk score to predict mortality in the first year after implantable cardioverter defibrillator implantation: Data from the Israeli ICD Registry
Key result
The AAACC risk score predicted 1-year mortality after ICD implantation with an area under the curve of 0.71 (95% CI 0.66-0.76), with risk increasing from 1% for 0 points to 12.5% for >4 points.
Why the study?
Does the AAACC risk score accurately predict 1-year mortality in patients undergoing ICD or CRT-D implantation?
Population
2,617 patients from the prospective Israeli ICD Registry who underwent implantable cardioverter…
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Implication
AAACC score may aid post-ICD risk stratification; hypothesis-generating and requires prospective validation before clinical adoption.
Study Design
Type
Cohort (n=2,617)
Multicenter
Yes
Structured PICO
Does the AAACC risk score accurately predict 1-year mortality in patients undergoing ICD or CRT-D implantation?
P
Population
2,617 patients from a prospective Israeli registry who underwent ICD or CRT-D implantation, followed for 1 year to develop a mortality risk score.
E
Exposure
Development and validation of the AAACC risk score (Age >75 years, Anemia, Atrial Fibrillation, Chronic Renal Failure, Chronic Lung Disease) to predict mortality.
O
Outcome
1-year mortality after ICD or CRT-D implantationhard clinical
Main Result
Effect estimate: AUC 0.71 (95% CI 0.66-0.76)
The AAACC risk score is a simple clinical tool that can identify patients at high risk of 1-year mortality after ICD implantation, potentially aiding in patient selection by identifying those who may not survive long enough to benefit from the device.
Cite This Study
Nevzorov et al. (2018) conducted a cohort in Implantable cardioverter defibrillator (ICD) or CRT-D implantation (n=2,617). AAACC risk score vs. Lower risk score was evaluated on 1-year mortality (AUC 0.71, 95% CI 0.66-0.76). The AAACC risk score predicted 1-year mortality after ICD implantation with an area under the curve of 0.71 (95% CI 0.66-0.76), with risk increasing from 1% for 0 points to 12.5% for >4 points.