Key result
ATP induced a Ca-free contraction in rat myometrium that was unaffected by smooth muscle relaxants but suppressed by the calmodulin antagonist W-7 and Mg removal, suggesting a Ca-independent process.
Population
Wistar rats pregnant for 18-20 days, and estrogen-treated rats; longitudinal muscle strips of the myometrium.
Comparison
Adenosine triphosphate in Ca-free solution vs Krebs solution and K-contracture
Design
Preclinical
Authors
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Does not inform clinical uterine management; leaves open Ca-independent ATP signaling as a hypothesis-generating mechanism in myometrium.
ATP induces a Ca-independent, Mg-dependent tonic contraction in rat myometrial smooth muscle.
OSA et al. (1987) studied Rat myometrium contraction. Adenosine triphosphate (ATP) in Ca-free solution vs. Krebs solution / K-contracture was evaluated on Contractile response (phasic and tonic contractions). ATP induced a Ca-free contraction in rat myometrium that was unaffected by smooth muscle relaxants but suppressed by the calmodulin antagonist W-7 and Mg removal, suggesting a Ca-independent process.
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