Why the study?
Does a 1-g intravenous injection of cefotetan achieve adequate intraperitoneal concentrations in patients undergoing elective gastrointestinal surgery?
Does a 1-g intravenous injection of cefotetan achieve adequate intraperitoneal concentrations in patients undergoing elective gastrointestinal surgery?
A 1-g intravenous dose of cefotetan provides adequate intraperitoneal concentrations to inhibit susceptible pathogens for at least 5 hours during abdominal surgery.
Answers are grounded in this paper and cite their sources.
May support cefotetan dosing for peritoneal coverage in GI surgery; leaves open confirmation of clinical efficacy in randomized trials.
The intraperitoneal penetration of cefotetan was studied after a 1-g intravenous injection in 25 patients undergoing elective gastrointestinal surgery. Levels of peritoneal fluid were high within 10 min after administration and increased to 44% of the serum levels after 30 min, rising to 115% at 3 h. The mean concentration of cefotetan between 3 and 5 h after administration was 32.3 micrograms/ml. These findings suggest that 1 g of cefotetan administered before abdominal surgery would result in intraperitoneal cefotetan levels necessary to inhibit susceptible pathogens for 5 h or more.
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Wise et al. (1983) studied this question.
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