Key result
Total artificial heart implantation for alternative indications showed a trend toward decreased survival to transplantation compared with biventricular heart failure (77% vs. 93%; HR 0.42; P=0.2).
Why the study?
Does survival to transplantation differ between patients receiving a Total Artificial Heart for alternative indications versus biventricular heart failure?
Population
66 patients undergoing Total Artificial Heart implantation, including those with biventricular heart failure…
Comparison
Total Artificial Heart implantation for… vs Total Artificial Heart implantation for…
Design
Cohort
Authors
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Does not support restricting total artificial heart use by indication; leaves open outcome equivalence in larger cohorts.
Cohort (n=66)
No
Does survival to transplantation differ between patients receiving a Total Artificial Heart for alternative indications versus biventricular heart failure?
Hazard Ratio: 0.42 (95% CI 0.1–1.7)
Absolute Event Rate: 77% vs 93%
p-value: p=0.2
Total artificial heart implantation is an effective bridge to transplantation, achieving an 86% overall survival rate with comparable outcomes between standard biventricular heart failure and alternative indications.
Thanavaro et al. (2014) conducted a cohort in Heart failure requiring total artificial heart implantation (n=66). Alternative (ALT) indications for TAH implantation vs. Biventricular heart failure (BiVHF) indications for TAH implantation was evaluated on Survival to transplantation (HR 0.42, 95% CI 0.1, 1.7, p=0.2). Total artificial heart implantation for alternative indications showed a trend toward decreased survival to transplantation compared with biventricular heart failure (77% vs. 93%; HR 0.42; P=0.2).
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