September 1, 1992Canadian Journal of Physiology and Pharmacology

Inhibition of nitrovasodilator- and acetylcholine-induced relaxation and cyclic GMP accumulation by the cytochrome P-450 substrate, 7-ethoxyresorufin

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Population

Isolated rat aorta

Design

Preclinical

Authors

BBBrian M. BennettQueen's University BMBernard McDonaldCross-Cutting Cardiology RNRita NigamImmunovaccine (Canada)

Discussion

Member takes

Implication

7-ER attenuates GTN and ACh relaxation in rat aorta; leaves open CYP450 role in GTN bioactivation pending human confirmation.

Structured PICO

Population

Isolated rat aorta

Intervention

7-ethoxyresorufin (7-ER) and resorufin

Outcome

Nitrovasodilator- and endothelium-dependent relaxation and cyclic GMP accumulationsurrogate

7-ethoxyresorufin inhibits nitrovasodilator- and acetylcholine-induced relaxation in rat aorta, providing evidence for the role of the cytochrome P-450 system in the biotransformation of GTN to nitric oxide.

Cite This Study

Bennett et al. (1992) studied this question.

synapsesocial.com/papers/6a9747374f01cef1e4af03e4 https://doi.org/10.1139/y92-181

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