Why the study?
Does immediate or delayed insulin replacement prevent or reverse myocardial structural changes in an animal model of severe chronic diabetes mellitus?
Population
Animal model of severe, chronic insulin-dependent diabetes mellitus
Comparison
Insulin treatment begun either immediately or… vs Untreated diabetic animals and nondiabetic animals
Design
Preclinical
Follow-up
Up to 26 weeks
Authors
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Prompt insulin may avert irreversible matrix remodeling in diabetic models; leaves open optimal timing for human cardiomyopathy prevention.
Does immediate or delayed insulin replacement prevent or reverse myocardial structural changes in an animal model of severe chronic diabetes mellitus?
Insulin treatment can prevent, but only selectively reverse, the progressive myocardial structural disorganization caused by severe diabetes, highlighting the importance of early glycemic control to prevent diabetic cardiomyopathy.
Erik W. Thompson (1994) studied this question.
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