Population
Preclinical models studying the murine A1 gene and hnRNP A1 pre-mRNA
Comparison
Conserved element and its 17-nucleotide sequence… vs Mutations in the AUGAGU sequence; addition of SR…
Design
Preclinical
Authors
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No direct clinical implications; extends mechanistic understanding of hnRNP A1 autoregulation of 5' splice site selection.
The study demonstrates that hnRNP A1 modulates 5' splice site selection on its own pre-mRNA through interaction with a specific intron element, without altering U1 snRNP binding.
Chabot et al. (1997) studied this question.
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