Key result
Norepinephrine administration significantly increased pulmonary vascular resistance (P > 0.01), suggesting active vasoconstriction in thoracotomized dogs.
Why the study?
Does norepinephrine administration affect pulmonary vascular resistance in thoracotomized dogs?
Population
11 thoracotomized dogs
Comparison
Norepinephrine (NE) administration vs Control state at corresponding average…
Design
Preclinical
Authors
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Indicates active pulmonary vasoconstriction with norepinephrine in dogs; leaves open relevance to human perioperative management.
Does norepinephrine administration affect pulmonary vascular resistance in thoracotomized dogs?
Norepinephrine administration causes active vasoconstriction and increases pulmonary vascular resistance in a canine model.
Patel et al. (1961) studied this question. Norepinephrine administration significantly increased pulmonary vascular resistance (P > 0.01), suggesting active vasoconstriction in thoracotomized dogs.
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