Key result
The ZS diagnostic model, based on serum concentrations of glycerophospho-N-oleoyl ethanolamine and monoglyceride (18:2), predicted bicuspid aortic valve with an AUC of 0.930, 76.7% sensitivity, and 90.0% specificity in the validation cohort.
Why the study?
Does a serum-based metabolomics profiling model accurately diagnose bicuspid aortic valve compared to healthy individuals?
Case-Control (n=100)
Single-blind (performers blind to clinical information during validation)
No
Does a serum-based metabolomics profiling model accurately diagnose bicuspid aortic valve compared to healthy individuals?
A novel serum-based metabolomics model using two metabolites demonstrates high diagnostic accuracy for the non-invasive screening of bicuspid aortic valve.
Bicuspid aortic valve (BAV) is the most common congenital heart disease. The current study aims to construct a diagnostic model based on metabolic profiling as a non-invasive tool for BAV screening. Blood serum samples were prepared from an estimation group and a validation group, each consisting of 30 BAV patients and 20 healthy individuals, and analyzed by liquid chromatography-mass spectrometry (LC-MS). In total, 2213 metabolites were detected and 41 were considered different. A model for predicting BAV in the estimation group was constructed using the concentration levels of monoglyceride (MG) (18:2) and glycerophospho-N-oleoyl ethanolamine (GNOE). A novel model named Zhongshan (ZS) was developed to amplify the association between BAV and the two metabolites. The area under curve (AUC) of ZS for BAV prediction was 0.900 (0.782-0.967) and was superior to all single-metabolite models when applied to the estimation group. Using optimized cutoff (-0.1634), ZS model had a sensitivity score of 76.7%, specificity score of 90.0%, positive predictive value of 80% and negative predictive value of 85.0% for the validation group. These results support the use of serum-based metabolomics profiling method as a complementary tool for BAV screening in large populations.
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Wang et al. (2016) conducted a case-control in Bicuspid Aortic Valve (BAV) (n=100). Serum metabolite diagnostic model (ZS model) vs. Healthy controls was evaluated on Area under the curve (AUC) for BAV prediction in the validation group. The ZS diagnostic model, based on serum concentrations of glycerophospho-N-oleoyl ethanolamine and monoglyceride (18:2), predicted bicuspid aortic valve with an AUC of 0.930, 76.7% sensitivity, and 90.0% specificity in the validation cohort.
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