Key result
Heart transplant recipients exhibited markedly lower power of low-frequency R-R interval fluctuations compared to normotensive controls (0.75 vs 5.62 ms2, P < 0.001).
Why the study?
Does the presence of non-respiration-related low-frequency oscillations in R-R interval indicate autonomic reinnervation in heart transplant recipients compared to healthy controls?
Population
23 heart transplant recipients (age 43 years, range 23-64 years) and 25 normotensive control subjects
Comparison
Assessment of spontaneous variability in R-R… vs Normotensive control subjects
Design
Cross-sectional
Authors
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Reduced LF R-R power in transplant recipients suggests incomplete reinnervation; leaves open whether LF oscillations mark autonomic recovery.
Observational (n=48)
Does the presence of non-respiration-related low-frequency oscillations in R-R interval indicate autonomic reinnervation in heart transplant recipients compared to healthy controls?
Absolute Event Rate: 0.75% vs 5.62%
p-value: p=< 0.001
The presence of non-respiratory low-frequency heart rate oscillations in heart transplant recipients, particularly late after transplantation, suggests evidence of autonomic reinnervation.
Bernardi et al. (1994) conducted an observational in Heart transplant recipients (n=48). Heart transplantation vs. Normotensive control subjects was evaluated on Natural logarithm of the power of low-frequency fluctuations in R-R interval (p=< 0.001). Heart transplant recipients exhibited markedly lower power of low-frequency R-R interval fluctuations compared to normotensive controls (0.75 vs 5.62 ms2, P < 0.001).
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