Key result
Leukocyte migration inhibition testing with measles virus antigen showed no significant differences between multiple sclerosis patients and healthy controls.
Why the study?
Does leukocyte migration inhibition in response to measles virus antigen differ between multiple sclerosis patients and healthy controls?
Case-Control
Does leukocyte migration inhibition in response to measles virus antigen differ between multiple sclerosis patients and healthy controls?
Leukocyte migration inhibition in response to measles virus antigen does not differ between multiple sclerosis patients and healthy controls.
Answers are grounded in this paper and cite their sources.
No diagnostic utility for this assay in MS; leaves open measles contribution to pathogenesis.
The leukocyte migration inhibiton test was used in multiple sclerosis patients and in healthy controls for investigation of sensitization of blood lymphocytes against preparations of measles virus, mumps, NDV virus, and PPD. Regardless of antigen used, no significant differences were found between the groups. There was a strong correlation between the leukocyte migration inhibition obtained with measles virus antigen and with PPD. The leukocytes from MS patients as well as from healthy controls showed a significantly more pronounced inhibiton when a Tween 80 and ether-treated preparation of measles virus was used, compared with the whole measles virus antigen. No correlations were found between the degree of leukocyte migration inhibition and the antibody titers against different components of measles virus in individual samples.
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Kinnman et al. (2009) conducted a case-control in Multiple sclerosis. Measles virus antigen preparations vs. Healthy controls was evaluated on Leukocyte migration inhibition. Leukocyte migration inhibition testing with measles virus antigen showed no significant differences between multiple sclerosis patients and healthy controls.
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