Key result
Oral glucose substantially lowered blood pressure in patients with chronic autonomic failure (area under curve -24.9%, P<0.001), whereas xylose caused a smaller fall (-8.9%, P<0.05).
Why the study?
Does carbohydrate ingestion (glucose vs xylose) contribute to postprandial hypotension in patients with chronic autonomic failure?
Population
6 patients with chronic autonomic failure and 8 normal subjects (total n=14)
Comparison
Oral glucose ingestion vs Iso-osmotic solution of oral xylose and normal…
Design
Other
Follow-up
120 minutes
Authors
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May warrant glucose restriction in autonomic failure to limit hypotension; leaves open confirmation of insulin-specific mechanisms in larger studies.
Does carbohydrate ingestion (glucose vs xylose) contribute to postprandial hypotension in patients with chronic autonomic failure?
Absolute Event Rate: -24.9% vs -8.9%
Carbohydrate components of a meal, particularly those causing insulin release, contribute to postprandial hypotension in patients with autonomic failure.
Mathias et al. (1989) studied Chronic autonomic failure (n=14). Oral glucose vs. Oral xylose was evaluated on Blood pressure change (area under curve). Oral glucose substantially lowered blood pressure in patients with chronic autonomic failure (area under curve -24.9%, P<0.001), whereas xylose caused a smaller fall (-8.9%, P<0.05).
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