Why the study?
Do anticonvulsant GABA-transaminase inhibitors possess antifibrillatory activity in the rabbit isolated heart compared to phenytoin and mexiletine?
Do anticonvulsant GABA-transaminase inhibitors possess antifibrillatory activity in the rabbit isolated heart compared to phenytoin and mexiletine?
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GABA-transaminase inhibitors lack antifibrillatory activity in rabbit isolated heart unlike phenytoin or mexiletine; leaves open any therapeutic implications.
1 The electrical stimulation and ventricular fibrillation thresholds were measured in the Langendorff-perfused rabbit heart by application of rectangular impulses of 3 ms duration and increasing current at frequencies of 4 and 20 Hz respectively. 2 Perfusion with either phenytoin or mexiletine produced significant dose-dependent increases in both thresholds. 3 Perfusion with four anticonvulsant inhibitors of gamma-aminobutyric acid (GABA)-transaminase, aminooxyacetic acid, gamma-acetylenic GABA, gamma-vinyl GABA and sodium valproate, up to a concentration of 20 microgram/ml, had no significant effect on either threshold. 4 The results suggest that these compounds, unlike phenytoin and mexiletine, are devoid of antifibrillatory activity.
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Almotrefi et al. (1980) studied this question.
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