Key result
Enalapril improved alveolar-capillary gas transfer, ventilation-perfusion coupling, and exercise tolerance in patients with idiopathic cardiomyopathy, but not in hypertensive controls.
Why the study?
Does enalapril improve pulmonary function and exercise capacity in patients with idiopathic cardiomyopathy?
Cohort (n=39)
Does enalapril improve pulmonary function and exercise capacity in patients with idiopathic cardiomyopathy?
ACE inhibition with enalapril improves alveolar-capillary gas transfer and ventilation-perfusion coupling in patients with left ventricular dysfunction, potentially explaining improvements in exercise tolerance.
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May support enalapril for exercise tolerance in idiopathic cardiomyopathy; leaves open confirmation in randomized trials.
Guazzi et al. (1999) conducted a cohort in Idiopathic cardiomyopathy and congestive heart failure (n=39). Enalapril vs. Control subjects with mild primary hypertension was evaluated on Pulmonary function and exercise capacity. Enalapril improved alveolar-capillary gas transfer, ventilation-perfusion coupling, and exercise tolerance in patients with idiopathic cardiomyopathy, but not in hypertensive controls.
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