Key result
Enalapril treatment significantly improved pulmonary diffusing capacity for carbon monoxide in patients with chronic heart failure by increasing alveolar capillary membrane conductance.
Why the study?
Does enalapril improve pulmonary diffusing capacity for carbon monoxide and its subcomponents in patients with chronic heart failure?
Does enalapril improve pulmonary diffusing capacity for carbon monoxide and its subcomponents in patients with chronic heart failure?
Angiotensin-converting enzyme inhibition with enalapril improves pulmonary gas transfer in chronic heart failure by restoring the diffusive properties of the alveolar capillary membrane.
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Enalapril may enhance pulmonary gas transfer in chronic heart failure; hypothesis-generating and requires randomized confirmation before practice change.
Guazzi et al. (1999) studied chronic heart failure (n=49). Enalapril vs. Placebo and isosorbide dinitrate was evaluated on Conductance of alveolar capillary membrane (DM) and capillary blood volume (VC). Enalapril treatment significantly improved pulmonary diffusing capacity for carbon monoxide in patients with chronic heart failure by increasing alveolar capillary membrane conductance.
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