Key result
Gene delivery by chimpanzee adenovirus type 68 (C68) occurs by a CAR-dependent mechanism, as transduction was blocked by anti-CAR antibody or soluble CAR extracellular domain.
Population
CHO cells expressing either human or murine coxsackievirus and adenovirus receptor (CAR)
Comparison
Chimpanzee adenovirus type 68 (C68) transduction vs Adenovirus type 5 transduction, or blockade with…
Design
Preclinical
Authors
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C68 supports CAR-dependent vectors in animal models; extends adenoviral platform data but should not yet change practice.
Gene delivery by chimpanzee adenovirus type 68 (C68) occurs via a CAR-dependent mechanism, similar to human adenovirus type 5.
Cohen et al. (2002) studied this question. Chimpanzee adenovirus type 68 (C68) vs. Adenovirus type 5 (Ad5) was evaluated on Transduction mechanism and interaction with CAR. Gene delivery by chimpanzee adenovirus type 68 (C68) occurs by a CAR-dependent mechanism, as transduction was blocked by anti-CAR antibody or soluble CAR extracellular domain.
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