Key result
Bretylium tosylate produced a satisfactory response with no further ventricular tachyarrhythmias in 60% (18 of 30) of patients with refractory arrhythmias.
Why the study?
Does bretylium tosylate suppress refractory ventricular tachyarrhythmias in patients unresponsive to multiple antiarrhythmic drugs?
Population
30 patients with ventricular tachyarrhythmias refractory to intensive therapy with up to five antiarrhythmic…
Design
Case_series
Follow-up
up to 15 months (for discharged patients)
Authors
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May support bretylium in refractory VT; hypothesis-generating from case series and requires prospective trials.
Observational (n=30)
Does bretylium tosylate suppress refractory ventricular tachyarrhythmias in patients unresponsive to multiple antiarrhythmic drugs?
Bretylium tosylate is effective in suppressing refractory ventricular tachyarrhythmias in a majority of patients unresponsive to standard antiarrhythmic therapy.
Bernstein et al. (1972) conducted an observational in Refractory Ventricular Arrhythmias (n=30). Bretylium tosylate was evaluated on Satisfactory response (no further ventricular tachyarrhythmias). Bretylium tosylate produced a satisfactory response with no further ventricular tachyarrhythmias in 60% (18 of 30) of patients with refractory arrhythmias.
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