Key result
Bretylium tosylate completely prevents inducible ventricular arrhythmias in post-MI dogs, reducing rates to ~0%.
Why the study?
The ability of chronic bretylium tosylate treatment to prevent induction of ventricular tachycardia after acute myocardial infarction was assessed.
Does bretylium tosylate prevent the induction of ventricular tachyarrhythmias in a canine model of acute myocardial infarction?
Comparison
Bretylium tosylate 5 mg/kg i.v. every 12 hours vs untreated control dogs
Design
Preclinical experimental study
Follow-up
Days 3-6 after acute myocardial infarction, up to 60 hours after drug withdrawal
Authors
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Hypothesis-generating in canine post-MI model; leaves open translation to human arrhythmia prevention.
Does bretylium tosylate prevent the induction of ventricular tachyarrhythmias in a canine model of acute myocardial infarction?
Absolute Event Rate: 0% vs 91.2%
Bretylium tosylate effectively prevents the induction of reentrant ventricular tachyarrhythmias after ischemic myocardial injury in a canine model.
Patterson et al. (1981) studied acute myocardial infarction (n=41). Bretylium tosylate vs. untreated control was evaluated on induction of ventricular arrhythmias. Bretylium tosylate completely prevented the induction of ventricular arrhythmias in dogs post-myocardial infarction (0% vs 91.2% in controls), with arrhythmias returning upon drug withdrawal.
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